Following 126,920 post-menopausal women for nine years, a Cancer Causes Control study tied current hormone therapy use to 29 percent higher ovarian cancer risk. Estrogen-only users were at 63 percent; the 20 percent rise for estrogen plus progestin was not statistically significant.
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Drug
Two genes linked to deadly ovarian cancer
Two New England Journal of Medicine studies identify mutations in ARID1A and PPP2R1A in ovarian clear cell carcinoma, an aggressive chemotherapy-resistant form that is about 12 percent of cases. A second team found ARID1A mutations in endometriosis-linked tumors too; the risk they carry is unclear.
Nutrition
Where can I learn about prostate or ovarian cancer?
September marks both National Prostate Cancer and National Ovarian Cancer Awareness Month. Using National Library of Medicine material, the post explains how tumors form and spread, then points to NCI, CDC and FTC resources and an FDA warning about online cancer fraud.
Food
Fruit and vegetables boost ovarian cancer survival
Among 341 women with epithelial ovarian cancer, those eating the most fruit and vegetables before diagnosis were 39 percent less likely to die by 2005. The heaviest meat eaters were 128 percent more likely to die and the heaviest milk-product users 115 percent. The study was observational.
Drug
Detection of early stage ovarian cancer may be possible
Researchers compared blood from 34 women with ovarian cancer and 70 without, testing six candidate proteins. Three began rising slightly about three years before diagnosis, though Garnet Anderson notes the levels do not look clearly abnormal until the final year before diagnosis.
Drug
Hormone therapy raises ovarian cancer risk
Among Danish women aged 50 to 79 followed from 1995 to 2005, current hormone therapy users were 38 percent more likely to develop ovarian cancer than never-users, and former users 15 percent more likely. Risk did not vary significantly by formulation, regimen or route.
Drug
HRT Increases Ovarian Cancer Risk
A Danish study reported in JAMA found women on hormone replacement therapy had a 38 percent greater risk of ovarian cancer than never-users. The absolute risk stays low, about one extra case per 8,300 women, and returns to normal two years after stopping.
Phytochemicals
Flavonoids reduce ovarian cancer risk
Harvard's Margaret Gates compared 1,141 women with ovarian cancer to 1,183 without and found those eating more apigenin — in celery, parsley, red wine and tomato sauce — were less likely to develop it. She stresses more research is needed before anything is definitive.
Drug
Early screening for ovarian cancer appears ineffective
A University of Alabama at Birmingham study questions CA-125 blood tests paired with ultrasound for early detection: the combination caught 70 percent of cancers only in late stages, and about 1.6 percent of positive results were true positives, driving unnecessary surgery.
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