Taiwanese researchers report that the vitamin D analog 19-nor-1alpha,25(OH)2D2 inhibited pancreatic tumor growth in vitro and in vivo by up-regulating the p21 and p27 tumor suppressor genes. Analogs aim to deliver the effect with fewer side effects than the most active form of the vitamin.
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Pancreatic Cancer
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Vitamins
Dietary folate does not reduce risk of pancreatic cancer
Following 120,852 Dutch adults for 13.3 years, researchers found those with the highest dietary folate intake ran a 37 percent higher risk of pancreatic cancer than those with the lowest, and found no link for individual folate vitamers.
Diet
Fatty diet linked to high risk of pancreatic cancer
Among more than 500,000 adults in the NIH-AARP study followed about 6.3 years, those eating the most saturated fat were 36 percent more likely to develop pancreatic cancer, rising to 43 percent for saturated fat from animal sources.
Phytochemicals
Nigella sativa extract may prevent pancreatic cancer
Thymoquinone, the main compound in Nigella sativa oil, almost completely shut down several inflammatory cytokines in pancreatic cancer cells and blocked NF-kappaB, outperforming trichostatin A, Thomas Jefferson researchers reported at the AACR 2009 meeting.
Cancer
Pancreatic cancer: What you need to know
Carnegie Mellon professor Randy Pausch, known for his last lecture, died of pancreatic cancer at 47. The disease was projected to be diagnosed in 37,680 Americans and kill 34,290 in 2008. Smoking is the main avoidable risk; a Karolinska study tied sweetened food and drink to higher risk.
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