In mice carrying human prostate tumors, combining a soy diet with calcitriol inhibited tumor growth more than either alone but also caused hypercalcemia and in some cases lethal toxicity, a study in Prostate found. Soy raised the bioavailability of calcitriol.
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Food
Avoid hormone therapy, instead use soy to fight hot flashes - studies suggest
Pooling 19 studies of more than 1,200 women, researchers found soy isoflavones cut the frequency and severity of hot flashes by up to 26% compared with placebo. At least 54 mg a day for six weeks to a year reduced hot flash frequency by 20.6%.
Supplements
Soy-based S-equol supplement reduces metabolic syndrome risk factors (PR)
A 12-week study reported at Women's Health 2012 found a fermented soy germ supplement containing S-equol lowered HbA1c and LDL cholesterol and improved vascular stiffness, especially in women. Otsuka Pharmaceutical sponsored the work; a coauthor works for its US arm.
Food
Soy lowers cholesterol
A JAMA study led by David Jenkins found six months on a diet of soy, nuts and plant sterols lowered LDL cholesterol about 14 percent against controls, beating a low-saturated-fat diet. A separate analysis of 43 studies put soy's LDL reduction at roughly 4 to 6 percent.
Food
Cholesterol lowering foods prevent heart disease
A JAMA study found six months on a diet built around soy foods, plant sterols and nuts cut LDL cholesterol by as much as 14 percent from baseline, against 3 percent for a low-saturated-fat, high-fibre diet. Two levels of clinic support produced similar results.
Nutrition
One study says soy isoflavones don't help hot flashes, another study says they do
A two-year randomized trial of 248 women aged 45 to 60 found 200 mg a day of soy isoflavones did not prevent bone loss or menopausal symptoms, and women taking them reported more hot flashes and constipation. An earlier Brazilian trial reached the opposite conclusion.
Diet
Low cal diet plus soy protein good for cholesterol
Fifty-two patients with hyperlipidemia followed a 1,400 kcal diet with 30 grams of soy protein daily for four weeks and ended with lower LDL and total cholesterol than controls. Everyone on the low-calorie diet lost weight and waist and hip circumference.
Food
Doctor Warns: Eat This and You’ll Look 5 Years Older
Mercola argues the claims that launched soy foods in the 1990s, from lowering cholesterol to easing hot flashes and preventing breast and prostate cancer, are mostly false, and calls the boom a marketing gimmick. He starts by unpacking soy protein isolate.
Food
Eating soybean may reduce risk of breast cancer
Women with the highest soy isoflavone intake were 30% less likely to have an invasive breast cancer, in a comparison of 683 breast cancer patients with 611 healthy women. The associations showed up only among premenopausal women, and the design cannot establish cause.
Phytochemicals
Pink news: Soy protein cuts risk of breast cancer death
Among 5,042 Chinese breast cancer survivors followed about four years, women with the highest soy protein intake were 29 percent less likely to die and 32 percent less likely to suffer a recurrence than those eating the least, a JAMA study reports.
Supplements
Soy supplements as effective as hormone therapy in easing menopausal symptoms
In a double-blind trial, 60 postmenopausal women took a 90 mg soy isoflavone supplement or hormone therapy for 16 weeks. Both eased hot flashes and muscle pain, by 49.8 and 45.6 percent, and vaginal dryness. Placebo matched them except on urogenital symptoms.
Cancer
Study: Soy and Brazil nuts fight prostate cancer
Genistein from soy and selenium from Brazil nuts, separately and together, slowed the growth of both hormone-dependent and hormone-independent prostate cancer cells and cut MMP-2 expression, with the combination most effective. Healthy prostate cells were unaffected.
Diabetes
Soy products beat drugs for type 2 diabetes prevention?
A five-year trial in more than 8,300 overweight adults found nateglinide prevented neither diabetes nor cardiovascular events, while valsartan modestly cut new diabetes without reducing cardiovascular risk. A Japanese cohort study separately tied soy and isoflavone intake to lower diabetes risk.
Nutrition
Eating veggies, fruit, soy cuts breast cancer risk
Among 34,000 Singapore Chinese women followed 10 years, those eating the most vegetables, fruit and soy were 30 percent less likely to develop breast cancer than those eating the least. At five years the reduction among postmenopausal women reached about 50 percent.
Food
Soy foods help prevent lung cancer in non-smokers
Among 76,661 Japanese adults followed 11 years, never-smoking men in the top quarter for isoflavone intake were 57 percent less likely to be diagnosed with lung cancer, with a similar pattern in never-smoking women. Current and former smokers showed no such link.
Supplements
Soy protein helps fight cancer and inflammation
University of Illinois researchers report that lunasin, a soy peptide recovered from soy-processing waste, triggered leukemia cell death through caspase-3 and reduced inflammation markers NF-kappa-B, interleukin-1 and interleukin-6. Eating 50 grams of soy protein for five days raised blood levels.
Nutrition
Do phytosterol reduce risk of heart disease? and more!
An AICR Q&A: 2 grams of phytosterols a day can lower LDL cholesterol about 10 percent in people with high cholesterol, though reaching that usually takes fortified products, and there is no known benefit at healthy levels. The writer knows of no research tying whey to prostate cancer.
Chemical
Hexane ignites soy controversy
An investigation by Cornucopia and Natural News reports that soybeans are bathed in hexane, a volatile gasoline by-product, during processing, leaving residues never tested for toxicity. Two processing plant hexane accidents injured 11 people and killed two workers.
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