Inactive ingredients or excipients are often used in drugs and dietary supplements without completely knowing their toxicity or safety.  A study in European Journal of Cancer suggests that talc used in anticancer drugs can actually promote diabetes mellitus in rats with hepatocellular carcinoma. Other studies show that nanoparticles such as titanium dioxide, silicone dioxide, and zinc oxide used in foods and cosmetic products may actually disrupt DNA potentially leading to the development of tumors or cancers.Rajbala Singh, Muhammad Afzalemail, Imran Kazmiemail, Firoz Anwaremail  Talc used in anticancer drugs is promoter for diabetes in hepatocellular carcinoma induced rats, European Journal of Cancer, Volume 50, Issue 1, Pages 247–248, January 2014