Thursday June 2, 2016 (foodconsumer.org) -- E. Giovannucci at Harvard T.H. Chan School of Public Health and colleagues conducted a case-control study and confirmed that total circulating 25-hydroxyvitamin D is associated with lower risk of colorectal cancer.The current study found women in the highest quintile of total vitamin D were 46% less likely to be diagnosed with colorectal cancer, compared to those in the lowest quintile. The levels of vitamin D binding protein, free vitamin D and bioavailable vitamin D were not significantly associated with risk of colorectal cancer.For women with colorectal cancer, blood samples collected prior to diagnosis were analyzed to determine total vitamin D, vitamin D binding protein, free vitamin D and bioavailable vitamin D.This could not prove that the association between the total vitamin D level and risk of colorectal cancer was a causal relation, meaning that supplementation with vitamin D may not lower the risk even though the possibility could not be ruled out either. Vitamin D deficiency has been linked to more than 17 types of cancers. Among other things, vitamin D is known to promote the production of antibacterial peptites and play an important role in innate immunity. (David Liu)Song M, Konijeti GG, Yuan C, Ananthakrishnan AN, Ogino S, Fuchs CS, Giovannucci E, Ng K, Chan AT. Plasma 25-Hydroxyvitamin D, Vitamin D Binding Protein, and Risk of Colorectal Cancer in the Nurses' Health Study. Cancer Prev Res (Phila). 2016 May 31.
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