In an 18-month JAMA trial, 2 grams of DHA daily did not slow decline in people with mild to moderate Alzheimer's: cognitive scores shifted 8.27 points against 7.98 for placebo, and an MRI substudy showed no effect on brain volume.
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Lifestyle
Heavy smoking in midlife boosts Alzheimer's disease risk
Among 21,123 people followed an average 23 years, those who smoked more than two packs a day in middle age had a 157 percent higher risk of Alzheimer's and a 172 percent higher risk of vascular dementia. Past smokers and those under half a pack showed no increase.
Vitamins
Could This be the Key Factor Spiking the Rise in Dementia and Alzheimer's?
In a two-year trial of 168 volunteers with mild cognitive impairment, brains of those taking high-dose folic acid, B6 and B12 shrank 0.76 percent a year against 1.08 percent on placebo. Mercola notes about half of people diagnosed with MCI go on to develop Alzheimer's within five years.
Other Diseases
Mediterranean diet helps costly, deadly Alzheimer's disease
A report by Alzheimer's Disease International puts 2010 dementia care costs at $601 billion, more than 1% of global GDP, for an estimated 35.6 million people worldwide, with cases expected to double by 2030. Wealthy countries hold 46% of cases and 89% of the costs.
Disease
Worldwide dementia care costs $601 billion in 2010 - report
Alzheimer's Disease International puts 2010 care costs for 35.6 million people with dementia at $601 billion, more than 1 percent of global GDP. The report expects cases to double by 2030 and more than triple by 2050, with costs rising fastest in the developing world.
Disease
Gene variant linked to aggressive Alzheimer's disease
Washington University researchers examined single DNA variations in 846 patients and reported in PLoS Genetics a variant tied to elevated tau in cerebrospinal fluid that tracked with faster Alzheimer's progression. Lead author Carlos Cruchaga says it held across three international studies.
Diabetes
On Diabetes, Mid-Life and Alzheimer's
A Neurology study tracked 135 people in a Japanese village for 10 to 15 years and found those with type 2 diabetes or related traits such as obesity, insulin resistance and high blood pressure were significantly more likely to develop the brain plaques seen in Alzheimer's.
Diabetes
Diabetes mellitus (Type 2) linked to Alzheimer's disease
Researchers followed 135 Japanese adults for 10 to 15 years and examined their brains after death: Alzheimer's plaques appeared in 72 percent of those with insulin resistance versus 62 percent without. No link emerged with tangles, and the lead author says cause is unproven.
Drug
Cerebrospinal Fluid Test Predicts Alzheimer's Disease
Three cerebrospinal fluid biomarkers formed a signature found in 90 percent of Alzheimer's patients, 72 percent of people with mild cognitive impairment and 36 percent of cognitively normal adults, Archives of Neurology reports. Having the profile does not mean a person will develop the disease.
Vitamins
Vitamin E rich foods cut dementia risk
Among 5,395 Dutch adults aged 55 and over, those eating the most dietary vitamin E were 25 percent less likely to develop dementia over 9.6 years; vitamin C, beta carotene and flavonoids showed no link. Whether vitamin E itself lowered the risk remains unknown.
Vitamins
Vitamin D deficiency linked to Alzheimer's disease
A Neurology study of 340 older adults receiving home care found those with insufficient 25(OH)D were 2.3 times more likely to have dementia, 2.5 times more likely to have Alzheimer's disease and twice as likely to have had a stroke. A separate review tied deficiency to lower cognitive scores.
Diet
Fatty Diet Could Cause Alzheimer's
Baylor researchers fed a high-fat diet to mice bred as a model of Alzheimer's disease and saw calorie intake climb from 12 weeks, amyloid beta-peptide levels rise alongside it, and the animals turn obese and insulin resistant by 16 weeks.
Diet
Plant-based diet may help depression, dementia
Vitamins
Does Depression Cause Alzheimer's Disease? Vitamin D Helps Both!
A Neurology study of 949 Framingham participants found 22 percent of those depressed at the start developed dementia over 17 years, against about 17 percent of the rest. Author Jane Saczynski says the data cannot show whether depression causes dementia or the reverse.
Other Diseases
Apple juice may help Alzheimer's patients
In an open-label trial, 21 people with moderate to severe Alzheimer's drank two 4-oz glasses of apple juice a day for a month. Cognitive and daily-living scores did not change, but caregivers reported improvement in behavioural and psychotic symptoms, chiefly anxiety, agitation and delusion.
Food
Diet linked to Alzheimer's disease risk
People aged 65 and over who ate more nuts, fish, tomatoes, poultry, cruciferous vegetables, fruit and leafy greens were up to 38 percent less likely to develop Alzheimer's over 3.9 years, in a study of 2,148 people. Those with the disease ate more high-fat dairy, red meat, organ meat and butter.
Vitamins
Serum vitamin E may protect against Alzheimer's disease
Following 232 dementia-free adults aged 80 and over for six years, Karolinska researchers found those in the top tertile for total vitamin E had about 45 percent lower Alzheimer's risk, and for tocotrienols 54 percent. Among individual forms, only beta-tocopherol stood out.
Diet
Healthy diet cuts Alzheimer's disease risk
Among 2,148 dementia-free adults aged 65 and older followed about four years, those eating more salad dressing, nuts, fish, poultry, tomatoes and leafy greens and less high-fat dairy, red meat, organ meat and butter were less likely to be diagnosed with Alzheimer's disease.
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