A case-control study in JAMA found women who used antibiotics for more than 1,000 days had roughly double the breast cancer risk of never-users, with risk climbing alongside cumulative days of use. The authors say more research is needed to show whether the link is causal or chance.
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Chemical
Chemical hazards: fluoride, pesticides, BPA and other contaminants.
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Chemical
Politics vs Science: Keeping the journal Fluoride out of PubMed
A Fluoride Action Network fundraising bulletin arguing that PubMed's refusal to index the journal Fluoride, published since 1968, is political. It quotes a Fluoride editorial blaming the U.S. health department's endorsement of water fluoridation as completely safe.
Chemical
FAN's Translation Project
The Fluoride Action Network describes its translation work: 48 foreign-language studies on fluoride toxicity translated between 2007 and 2012, and 19 more since October, covering musculoskeletal, cardiovascular, nervous system and male reproductive effects.
Chemical
Aspartame controversy: Aspartame linked to antioxidant imbalance, mild vascular congestion
Rats given 1,000 mg/kg of aspartame daily for 180 days had lower reduced glutathione and glutathione reductase activity in the brain, plus mild vascular congestion. The article notes a 75-kg adult would have to drink 417 cans of diet soda a day to reach that dose.
Chemical
Zinc oxide causes damage to the heart, lipoic acid, vitamin E help reduce the toxicity
Rats given high doses of zinc oxide nanoparticles for five days showed heart damage and raised inflammatory markers including TNF-alpha, IL-6 and CRP. Alpha-lipoic acid or vitamin E significantly reduced the toxicity, and the authors say early treatment with either may offer protection.
Chemical
Titanium dioxide nanoparticles cause damage to kidneys
A Journal of Oleo Science study found oral doses of 600 or 1,000 mg/kg of titanium dioxide nanoparticles for five days raised kidney-function and inflammatory markers and lowered glutathione, with worse effects at the higher dose. Quercetin or idebenone significantly reduced the harm.
Chemical
Acrylamide may cause some breast cancers
Among 62,573 Dutch women followed for 13 years, never-smokers with the highest acrylamide intake were 31 to 47 percent more likely to develop hormone receptor-positive breast cancer than those with the lowest. No link appeared for overall or receptor-negative breast cancer.
Chemical
Lycopene lowers toxicity of fluoride
Twenty-four rats were split into four groups for five weeks. Sodium fluoride raised oxidative stress and lipid peroxidation in red blood cells, heart and brain tissue and lowered glutathione and antioxidant capacity; rats given lycopene an hour beforehand had those changes normalized.
Chemical
Dietary cholesterol increases serum cholesterol
In an early study, 75 men and 18 women ate a fat-free diet for eight days, then the same diet with cholesterol added in butter oil. Serum cholesterol rose with intake, by 25.3 mg per 100 ml at the lowest level and 71.7 mg per 100 ml among those consuming 2,494 mg a day.
Chemical
Trans Fat: Taking the Next Important Step
FDA's Michael Taylor writes that trans fat raises LDL cholesterol and heart disease risk, that U.S. intake fell from 4.6 grams a day in 2003 to about 1 gram in 2012, and that eliminating industrially produced trans fat could prevent 20,000 heart attacks and 7,000 deaths a year.
Chemical
Again trans fat linked to higher all-cause death risk
A study in the American Journal of Clinical Nutrition followed 18,513 REGARDS participants for seven years. After adjustment, those eating the most trans fat faced a 24% higher risk of death from any cause than those eating the least; researchers tied 7% of population deaths to trans fat.
Chemical
Cracking Nut-Allergy Mechanisms
Agricultural Research Service chemists in New Orleans are studying how nut allergens interact with the immune system, including peptide differences between raw and cooked peanuts that may drive reactions. The piece notes food allergy rose 18% between 1997 and 2007.
Chemical
Contaminants in US Meat
A rundown of what US meat carries. FSIS finds antibiotic residues above legal limits every week, including drugs whose labels warn against human use, and bacteria persist anyway: nearly half of supermarket beef, chicken, pork and turkey samples held staph, some of it MRSA.
Chemical
Fluoride may be your next contraceptive?
NIH researchers compared silicofluorides with sodium fluoride in the test organism C. elegans and found all the fluoride chemicals in current use similarly toxic to growth, feeding and reproduction. The piece notes earlier work tying sodium fluoride to impaired sperm chemotaxis.
Chemical
Can Adding Fluoride to Milk Help Improve Children’s Dental Health?
Blackpool Council's health board has proposed adding fluoride to primary school milk; 43 percent of the town's 12-year-olds have at least one unhealthy tooth against 33.4 percent nationally. Ten other UK areas already do it, and a councilor says school dental programs should expand too.
Chemical
New Zealand's Fluoridation Status Hangs in the Balance
Fluoride Action Network New Zealand asks readers to help fund a TV Ondemand advertisement and billboards ahead of three fluoridation referenda held alongside local body elections. Hamilton's council voted to stop fluoridation, then agreed to put it to a referendum.
Chemical
Titanium dioxide nanoparticles damage organs
J. Xu of Ningbo University and colleagues gave mice single IV doses of titanium dioxide nanoparticles up to 1387 mg/kg and saw damage to brain, lung, spleen, liver and kidneys. The highest dose killed some mice within two days; no long-term effects were examined.
Chemical
Toxic nanoparticles might be entering human food supply (PR)
University of Missouri researchers developed a method to detect silver nanoparticles in fresh produce and tested it on pears dipped in a nanoparticle solution, then washed and rinsed repeatedly. Food scientist Mengshi Lin says the toxicity of these particles is not yet known.
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