In Medicare survey and claims data, people using any antidepressant with diagnosed depression had a 9.5 percent three-year diabetes rate against 4.8 percent in those with neither. The link weakened after adjusting for depression, which itself doubled the risk.
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Drug
Prescription drugs, vaccines and their risks and benefits.
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Drug
Why Taking Antibiotics During Pregnancy is a Bad Idea
Danish research found children whose mothers took antibiotics during pregnancy were 17% more likely to be hospitalized for asthma before age five, and twice as likely if the mother had asthma and used antibiotics in the third trimester. The study cannot separate the drugs from the infections.
Drug
Statins cause muscle pain or myalgia
Writing in Expert Review of Cardiovascular Therapy, J.J. DiNicolantonio notes that statins inhibit the mevalonate pathway and lower CoQ10 in muscle mitochondria, which he says may partly explain the muscle pain that leads many patients to quit the drugs.
Drug
Hepatocellular carcinoma risk may be reduced with statins
A Gastroenterology review pooling ten studies of 1.46 million people found statin users 37 percent less likely to develop hepatocellular carcinoma, 48 percent among Asians and 33 percent among Westerners. The piece cautions the link may not be causal and calls for trials.
Drug
90 Percent of Melanoma Surgeries are Unnecessary, Study Finds
A Journal of the American Academy of Dermatology report covering 300,215 melanoma excisions in 13 countries found unnecessary removals of benign lesions outnumbered needed excisions up to 30 times at non-specialized clinics. Its author ties this to awareness campaigns driving patients in.
Drug
Let's End the Prescription Drug Death Epidemic
Mercola reports one American dies every 19 minutes from an accidental prescription drug overdose, citing Sanjay Gupta on the scale of opioid painkiller deaths and congressional testimony that Americans consume 80 percent of the world's pain pills.
Drug
Science Behind Tamiflu Recommendations “Missing in Action”
Cochrane Collaboration researchers are questioning Tamiflu's effectiveness and the evidence behind the recommendations that led governments to stockpile it, Mercola writes. The piece also notes 150 Cincinnati health care workers face dismissal unless they get a flu shot.
Drug
20% dying cancer patients get radiation therapy in last 30 days of life
Reviewing claims for 202,299 people who died of lung, breast, prostate, colorectal or pancreatic cancer between 2000 and 2007, researchers found 7.6% had radiation therapy in their last month, and 17.7% of those for more than 10 days. Race, gender, income and hospice care were linked to its use.
Drug
ADHD drugs can lead to adverse cardiovascular events in some patients
A CNS Drugs review found ADHD stimulants generally safe and well tolerated, with small but statistically significant rises in blood pressure and heart rate at all ages. The authors urge caution when prescribing to patients with a family history of cardiovascular disease.
Drug
General Health Checkups and Medical Screening Tests—Do You Really Need Them?
Cassels, a drug policy researcher at the University of Victoria, argues in Seeking Sickness that medical screening is diagnosis rather than prevention, that some tests are inaccurate or harmful, and that screening funnels more and more people into drug regimens.
Drug
Venlafaxine may be used to treat ADHD
A review of three uncontrolled and two double-blind trials by A. Ghanizadeh's team suggests venlafaxine may work short-term for ADHD in children and adolescents, with fewer adverse effects than methylphenidate. The reviewers caution that larger, longer trials are needed first.
Drug
Mammogram screening per se can lead to breast cancer
Among 762,506 Spanish women screened between 1990 and 2006, a Cancer Epidemiology study found those given a fine-needle aspiration or a biopsy after a false-positive result were 2.69 and 1.81 times as likely to be diagnosed with breast cancer as women who had imaging alone.
Drug
New Risks Cited for Popular Sleeping Pill
The FDA warned in 2007 that Ambien and 12 other sleeping pills can trigger sleep-driving, phone calls and eating. The Mayo Clinic now says it will stop prescribing Ambien to inpatients, citing its strong correlation with falls among 16,000 hospitalized patients.
Drug
Diabetes drug may help fight breast cancer
In 125 postmenopausal women with breast cancer but no diabetes, taking 1,500 mg of metformin a day significantly lowered serum insulin and testosterone. Because both are tied to breast cancer risk and prognosis, the authors suggest metformin may have a role.
Drug
Dyslipidemia boosts myocardial infarction risk in those with chronic kidney disease
Among 142,394 Swedes followed 12 years, those in the top quartile of the apoB/apoA-1 ratio were 235% more likely to suffer a heart attack if they had chronic kidney disease, against 188% for those without it. The total cholesterol to HDL ratio showed a similar pattern.
Drug
Ultraviolet radiation, vitamin D protect against multiple sclerosis
In a Swedish case-control study of 1,013 multiple sclerosis cases and 1,194 controls, low ultraviolet exposure was tied to 120 percent higher risk and vitamin D below 50 nM/L to 40 percent higher risk. The UV link held after adjusting for vitamin D, suggesting other pathways are involved.
Drug
Avastin can lead to acute vision loss
A Korean report in the Journal of Ocular Pharmacology and Therapeutics describes four patients with ocular ischemic syndrome or central retinal vein occlusion who lost vision within a week of an Avastin injection. The authors urge extreme caution; whether the patients recovered is not stated.
Drug
Hormone replacement therapy raises stroke risk
Analysing Women's Health Initiative trial data, Stanford and Columbia researchers report that standard hormone therapy raised stroke risk in postmenopausal women by 33%, and adding progestogen did not lower it. For women under 60 that meant 2 extra strokes per 10,000 person-years.
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