Chinese researchers compared 30 postmenopausal heart attack patients with 6 controls and found higher oestrone, oestradiol, androstenedione and testosterone and lower SHBG in the cases. After adjusting for confounders, women with the highest oestradiol faced nearly five times the risk.
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Drug
Prescription drugs, vaccines and their risks and benefits.
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Drug
Antibiotic Alert: The Drug the Doctor Ordered Could Cause Deadly Side Effects
Mercola argues fluoroquinolones such as Cipro and Levaquin belong only in the most serious infections, not sinus, urinary tract and ear complaints. The FDA required black-box warnings on seven of them in 2008 for tendinitis and a three- to fourfold higher risk of tendon rupture.
Drug
Postoperative tamoxifen does not cut death risk in breast cancer patients
A Cochrane review of two trials covering 3,375 women found tamoxifen after surgery for ductal carcinoma in situ reduced recurrence of DCIS and of contralateral invasive breast cancer, but did not lower all-cause mortality. One follow-up tied it to more endometrial cancer.
Drug
Enzalutamide extends survival in castration-resistant prostate cancer patients
In a phase 3 trial of 1,199 men with castration-resistant prostate cancer after chemotherapy, enzalutamide brought median survival of 18.4 months against 13.6 months on placebo, and 54 percent of users saw PSA reductions versus 2 percent on placebo.
Drug
New Evidence Demolishes Claims of Safety and Effectiveness of HPV Vaccine
A Canadian team's systematic review of pre- and post-licensure HPV vaccine trials concludes the trial designs and the reading of both efficacy and safety data were largely inadequate, and finds evidence of selective reporting, leaving the vaccines' effectiveness unproven.
Drug
Confirmed Again: Statin Drugs Accelerate Cardiovascular Disease
Mercola cites a study in Atherosclerosis of 6,673 people with no known coronary disease in which statin use was associated with 52 percent greater prevalence and extent of calcified coronary plaque, alongside a Diabetes Care study tying frequent statin use to more calcification.
Drug
It Slashed Flu Deaths by 50% in 1918, What Can it Do For You Today?
Mercola interviews Dr. Robert Rowen on oxidative medicine, therapies using oxidants such as ozone, ultraviolet blood irradiation and intravenous hydrogen peroxide, which Rowen says are used for conditions ranging from viral and fungal infections to joint pain and arthritis.
Drug
Would You Take A Second Bone Drug From This Company?
The writer revisits Merck's 1999 predictions for Vioxx, Singulair and Fosamax, notes Vioxx's 2004 withdrawal and later warnings on the others, and describes how the company marketed osteopenia to widen the market for bone drugs now suspected of causing fractures and jawbone death.
Drug
Sexual Health: Antihypertensive drugs can cause sexual dysfunction
Sexual dysfunction appears more often in people with high blood pressure, and treated patients report it more than untreated ones, which the authors read as evidence the drugs contribute. Older diuretics and beta blockers are implicated; nebivolol and angiotensin receptor blockers appear neutral.
Drug
NSAIDs linked to high blood pressure
A survey of 2,805 people over 60 in Dubbo, Australia found NSAID use was associated with a 40 percent higher risk of high blood pressure after adjustment. A quarter of the group used NSAIDs, and the authors urge doctors to review their prescribing for elderly patients.
Drug
Nonaspirin NSAIDs increase lung cancer death risk
In the VITAL cohort of 785 lung cancer patients, NSAID use before diagnosis did not lower the risk of dying from the disease. Nonaspirin NSAIDs overall were linked to 20 percent higher risk of lung cancer death, and heavy ibuprofen use to 62 percent higher risk.
Drug
Do You Have Adult ADHD? Big Pharma Thinks So
With 4.5 million US children already labeled with ADHD, a 2008 market research release told drugmakers the adult population was twice the size and largely untapped. The piece argues the DSM-5 draft symptom list is loose enough that almost anyone can appear to qualify.
Drug
Chinese medicine comparable to HRT for menopause symptoms?
In a trial of 31 women, a Traditional Chinese Medicine preparation improved hot flashes and night sweats by 30 percent, the same as placebo, while hormone replacement therapy improved them by 50 percent. Researchers reported no qualitative improvement in patients' quality of life.
Drug
Shocking Dangers of Plavix Revealed in 2nd Comparison Study
Mercola returns to Plavix, the anti-platelet drug, saying new research on pairing it with aspirin to prevent stroke and cognitive decline confirms his earlier warning that the combination nearly doubled heart disease deaths among at-risk patients who had not had a heart attack.
Drug
Antidepressant drugs raise glaucoma risk
A case-crossover study of 6,470 Ontario residents aged 66 and older found those who had recently taken any antidepressant were 62 percent more likely to develop acute angle-closure glaucoma. The authors urge clinicians to watch for this uncommon but serious adverse event.
Drug
NSAIDs raise heart risk after myocardial infarction
Among 99,187 Danish patients treated for a first heart attack, 44 percent received NSAID prescriptions afterward. Any NSAID use was tied to a 59 percent higher risk of death at one year and 63 percent at five years. The authors advise long-term caution after a heart attack.
Drug
New England Compounding Center Issues Voluntary Nationwide Recall of All Products
New England Compounding Center recalled all products in circulation from its Framingham, Massachusetts facility on October 6, 2012, citing potential contamination risk. Clinics and providers should stop using the products, retain them and follow the faxed instructions.
Drug
Progestins plus estrogen not safer than estrogen alone
Drawing on Nurses' Health Study follow-up through 1992 and 1,935 breast cancer cases, researchers reported in the New England Journal of Medicine that current users of estrogen alone had a 32% higher risk and users of estrogen plus progestin 41%, versus never-users.
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