Among 4.1 million people in Puglia, Italy, low-dose aspirin users had a 55 percent higher rate of major gastrointestinal or cerebral bleeding than non-users, the JAMA study found. People with diabetes bled at a high rate whether or not they took aspirin.
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Drug
Prescription drugs, vaccines and their risks and benefits.
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Drug
Ketamine helps fight depression in ovarian cancer patient
A case report in the Journal of Palliative Medicine describes a woman with metastatic ovarian cancer whose depressive symptoms remitted after each of six intramuscular ketamine injections; pain improved too, though more briefly. The authors call it a possible antidepressant option.
Drug
Influenza Deaths: The Hype vs. the Evidence
Barbara Loe Fisher criticizes the annual push to sell flu shots, noting the CDC moved from recommending them for seniors and the chronically ill in the 1990s to everyone over six months old, and that Connecticut and New Jersey now require the shot for daycare.
Drug
Are You Concerned Over Genetically Modified Vaccines?
Dr. Mercola interviews Vicky Debold of the National Vaccine Information Center about genetically modified vaccines, some already on the CDC schedule. He quotes a 2006 toxicology paper warning that engineered virus-vector vaccines carry unpredictable hazards, including gene transfer.
Drug
Psychotropic Drug Use Associated with Increased Risk for Car Crashes
A study in the British Journal of Clinical Pharmacology found people in car accidents were more likely to have been taking benzodiazepines, antidepressants or Z-drug sleep aids, with risk often rising at higher doses. Researchers suggested doctors warn patients about driving.
Drug
Why Are So Many Children on Drugs?
The piece argues drug makers' awareness campaigns push parents, teachers and clinicians to medicate children at the first sign of trouble, citing marketing for Risperdal and Seroquel and noting that pediatric schizophrenia affects perhaps one child in 10,000 to 30,000.
Drug
Hormone Therapy raises Risk of Ulcerative Colitis but not Crohn's Disease
Tracking 108,844 postmenopausal women in the Nurses' Health Study, Hamed Khalili's team found that women who ever used hormone therapy were at least 65 percent more likely to develop ulcerative colitis, with no matching rise in Crohn's disease. Risk fell after stopping.
Drug
Antidepressant medications linked to type 2 diabetes mellitus
A Harvard meta-analysis of three large U.S. cohorts found antidepressant users had a 68 percent higher age-adjusted risk of developing type 2 diabetes. The excess fell to 30 percent after adjusting for other risk factors and to 17 percent after accounting for body mass index.
Drug
Newer Drugs for Rheumatoid Arthritis All Have Similar Risks -- Maybe It’s Time to Go Natural?
A safety analysis of Humira, Enbrel and Remicade found no difference in death rates among the more than 6,000 rheumatoid arthritis patients who started one of the three between 2003 and 2008; 211 died over five years. Serious side effects can include infection and cancer.
Drug
HIV/AIDS Update - Tentative approval of Lamivudine, Nevirapine and Zidovudine Fixed Dose Combination Scored Tablets for Oral Suspension
FDA granted tentative approval to a fixed-dose lamivudine, nevirapine and zidovudine tablet for HIV-1 in children weighing 5 to 25 kg. Patents bar U.S. marketing, but the Strides Arcolab product can be bought abroad under PEPFAR. It is the 153rd approval under the program.
Drug
Hormone replacement therapy boosts breast cancer risk
A Breast Cancer Research study of the European EPIC cohort weighed body mass index, waist and hip size and hormone replacement therapy against breast cancer subtypes. Among postmenopausal women who never used HRT, the highest BMI tertile carried a 47 percent higher risk.
Drug
Anti-osteoporosis drugs cause osteonecrosis of the jaw
Among 128 patients diagnosed with bisphosphonate-related osteonecrosis of the jaw in Seoul, three had received kidney transplants. All had taken oral bisphosphonates for more than two years and had high blood pressure, diabetes and a history of high-dose corticosteroids.
Drug
FDA MedWatch - CORRECTION Intestinomicina (contains chloramphenicol) by Laboratorios Lopez: Safety Alert - Contains Drug Ingredient Withdrawn from US
The FDA warns consumers not to use Intestinomicina, an El Salvador-made remedy for infectious diarrhea sold in some international grocery stores, because it contains chloramphenicol. Oral chloramphenicol left the U.S. market in July 2012 over bone marrow toxicity that can rarely be fatal.
Drug
Doctor Tells How To Get Off Dangerous Psychiatric Drugs in New Book
Psychiatrist Peter Breggin discusses Psychiatric Drug Withdrawal, his book aimed at prescribers and therapists, which covers the harm psychiatric drugs cause and how to approach withdrawal, and gives family and non-prescribing therapists equal weight in treatment.
Drug
The Latest Sneak Attacks in a Coordinated Effort to Eliminate Vaccine Exemptions
Mercola responds to a Children's Hospital of Philadelphia newsletter article that criticizes personal belief vaccine exemptions, arguing it relies on scare tactics and forms part of a coordinated effort to eliminate all vaccine exemptions.
Drug
Confirmed! Flu Vaccine INCREASES Risk of Serious Pandemic Flu Illness
Mercola reports Canadian research led by Danuta Skowronski finding that people who got the 2008-09 seasonal flu shot appeared more likely to be infected with pandemic H1N1, with five provincial studies showing the same result and an Australian expert citing about double the risk.
Drug
Heart disease risk higher in prostate cancer patients under treatment
Among 39,051 Swedish men, those with prostate cancer but no endocrine therapy had 8% and 10% higher risks of ischemic heart disease and stroke. The 8,168 who began endocrine treatment had a 40% higher risk of ischemic heart disease during treatment; stroke risk did not rise.
Drug
Some diabetes type 2 drugs raise bladder cancer risk
A CMAJ meta-analysis of 10 studies covering 2.65 million type 2 diabetes patients found cohort data linking thiazolidinediones to a 15 percent higher bladder cancer risk and pioglitazone to 22 percent. Rosiglitazone showed no association, and the authors call the evidence limited.
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