An Australian study of 43,405 postmenopausal women aged 45 and over, none of them hypertensive before menopause, found those using menopausal hormone therapy had higher odds of high blood pressure. Earlier trials had already linked the therapy to breast cancer and heart disease.
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Drug
Prescription drugs, vaccines and their risks and benefits.
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Drug
Osteoporosis drugs may or may not raise myocardial infarction risk
A Danish cohort of 103,562 bisphosphonate users and 310,683 matched controls tied low adherence to alendronate to roughly 50 percent higher risk of heart attack and coronary atherosclerosis, while higher adherence went with lower risk. Etidronate and raloxifene showed no such link.
Drug
Thiazide-type diuretics less likely to cause cardiovascular outcomes in diabetes patients
Among 22,418 ALLHAT participants, people who developed diabetes while taking the diuretic chlorthalidone had lower, non-significant risks of cardiovascular, all-cause and non-cardiovascular death than those who developed diabetes on amlodipine or lisinopril.
Drug
Government's Suicide Initiative Ignores Suicide-Linked Drugs
Surgeon General Regina Benjamin's suicide plan puts $55 million into hotlines, VA mental health staff, depression screening and Facebook monitoring, but says nothing about drugs carrying suicide warnings, the writer argues, naming antidepressants, antipsychotics, Singulair, Chantix and Accutane.
Drug
Qualitest Hydrocodone Bitartrate and Acetaminophen Tablets Recalled
Qualitest is recalling one lot of hydrocodone bitartrate and acetaminophen tablets, 10 mg/500 mg, because bottles may hold oversized tablets with more acetaminophen than intended, risking liver toxicity. Lot C1440512A shipped nationwide between May 14 and Aug. 3, 2012.
Drug
Fertility drugs promote ovarian cancer if they fail as fertility drugs
A study drawing on 902 ovarian cancer cases and 1,802 controls found no overall link between fertility drug use and ovarian cancer, but women who used the drugs and never became pregnant were about three times as likely to develop it as those who conceived.
Drug
CDC Preparing for New Swine Flu – Should You?
The CDC has counted 154 human infections with the swine flu variant H3N2v, mostly in people who had direct contact with pigs at county fairs. The agency says the virus still spreads to humans only with difficulty and appears to cause mild disease.
Drug
Aspirin may help patients undergoing cardiac surgery
Among 2,868 cardiac surgery patients at two hospitals, those who took aspirin within five days before surgery had a 62 percent lower 30-day death risk and fewer major cardiocerebral events after adjustment, the Annals of Surgery study reports. Readmissions did not differ.
Drug
X-ray boosts breast cancer risk
A questionnaire study of 16,314 people in China found x-ray exposure, family history of breast cancer, benign breast disease and high cholesterol each associated with elevated breast cancer risk. Thirty-three subjects reported a history of the disease.
Drug
Celecoxib doesn't help hormone therapy to treat prostate cancer
In a randomised trial of 2,114 men reported in the Journal of Clinical Oncology, adding celecoxib to long-term hormone therapy did not improve disease-free survival in prostate cancer. Toxicity was similar in both arms, and patients on the drug were told to stop.
Drug
Statins moderately cut risk of sudden cardiac death
A European Heart Journal analysis of 29 trials with 113,568 participants found statin users had about 10% lower risk of sudden cardiac death and 22% lower risk of other non-sudden cardiac deaths, but no reduction in ventricular tachyarrhythmia or cardiac arrest.
Drug
Why Did the FDA Approve a Generic Version of this Dangerous Drug?
Mercola questions FDA's approval of Mylan's generic pioglitazone while Actos faces thousands of lawsuits alleging heart failure, macular edema and bladder cancer. The drug carries a boxed warning that it may cause or worsen heart failure.
Drug
Bariatric surgery safe and effective at helping people with obesity, surgeons say
Lodhia and Morton reviewed 834 cases of patients averaging 45 years who received bariatric surgery between 2006 and 2010, with an average BMI of 46.2 and four comorbidities beforehand. They argue the procedure stays underused for obesity even as it gains popularity.
Drug
Bosutinib tablets for chronic myelogenous leukemia
FDA approved bosutinib (Bosulif) for Ph+ chronic myelogenous leukemia in adults resistant to or intolerant of prior therapy, based on a single-arm trial of 546 patients. Among chronic phase patients with one prior TKI, 33.8 percent reached a major cytogenetic response by week 24.
Drug
New Charges of Fraud on Heels of Abbott’s $1.5 Billion Plea Agreement
Weeks after Abbott settled charges of promoting its seizure drug Depakote for uses the FDA never approved, a former saleswoman's whistleblower suit, filed in 2009 and recently unsealed, alleges the company also promoted its cholesterol drug TriCor off-label.
Drug
The Latest Sneak Attacks in a Coordinated Effort to Eliminate Vaccine Exemptions
Mercola criticises a Children's Hospital of Philadelphia newsletter for attacking personal belief vaccine exemptions, and reports that the Gates Foundation gave a University of Connecticut professor $100,000 to set up an Anti-Vaccine Surveillance and Alert System.
Drug
Good cholesterol does not cut myocardial infarction risk
Two Mendelian randomization analyses in the Lancet found that genetic variants raising HDL cholesterol were not linked to lower myocardial infarction risk, while genetically higher LDL was, suggesting HDL may not be what drives the protection seen in observational studies.
Drug
4 Dead in 24 Hours After This Heart-Breaking Medical Mistake
Mercola reports four infants aged nine to 14 months in the Doti area of Nepal died within 24 hours of measles and DPT shots, with the district health office's preliminary investigation pointing to the measles vaccine. Two more children were hospitalized and a committee is investigating.
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