Among 5,955 men treated for localized prostate cancer, those on anticoagulants had lower prostate cancer death at 10 years, 3% versus 8%, with aspirin most strongly associated. The authors stress this was not a trial and no causal link is established.
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Drug
Prescription drugs, vaccines and their risks and benefits.
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Drug
Chemotherapy boosts heart failure/cardiomyopathy risk in breast cancer patients
Among 12,500 women treated for invasive breast cancer, those given anthracycline alone were 40 percent more likely to develop heart failure or cardiomyopathy than women who had no chemotherapy, while trastuzumab users were 4.12 times and combined users 7.19 times as likely.
Drug
Nearly Half of U.S. Doctors Struggling with Burnout
Of nearly 7,300 doctors surveyed for the Archives of Internal Medicine, almost half showed at least one symptom of burnout, 38% high emotional exhaustion and 30% high depersonalization, twice the rate of other working adults. Frontline specialties reported close to 60%.
Drug
Shocking Secrets about Clinical Trials: 2,061 Trial-Related Deaths. Yet Only 22 Were Compensated
A Right to Information query by medical rights activist Anand Rai found more than 2,000 people in India died from serious adverse events during drug trials between 2008 and 2011. Only 22 cases, about 1 percent, drew compensation, averaging roughly $4,800 per family.
Drug
Radical prostatectomy not needed for localized prostate cancer
In a New England Journal of Medicine trial, 731 men with localized prostate cancer were randomly assigned surgery or observation. After a median 10 years, 47% of the surgery group and 49.9% of the observation group had died; surgery cut neither mortality measure.
Drug
Early Pertussis vaccination may boost mortality in low-birth weight babies
Among 2,320 low birth weight newborns, girls given early diphtheria-tetanus-pertussis vaccine were 2.45 times as likely as unvaccinated girls to die within six months, rising to 5.68 times after adjustment for nutritional status, while vaccinated boys appeared to fare better.
Drug
The Hidden Causes of Psychiatric Disorders That Few Suspect
Mercola argues that atypical antipsychotics approved for schizophrenia and bipolar disorder are now prescribed off-label for anxiety, ADHD, behavior problems and insomnia, even to children as young as 18 months. He cites billion-dollar settlements over illegal marketing.
Drug
Confirmed: India’s Polio Eradication Campaign in 2011 Caused 47,500 Cases of Vaccine-Induced Polio Paralysis
Mercola cites a paper in the Indian Journal of Medical Ethics estimating 47,500 extra cases of non-polio acute flaccid paralysis in India in 2011, an incidence the researchers reported was directly proportional to the number of oral polio vaccine doses received.
Drug
Are There Food Options To Lower Cholesterol? This Expert Says Yes.
Cardiologist Barbara H. Roberts, author of The Truth About Statins, tells Martha Rosenberg there is little evidence behind the drugs' near-universal use, notes that most trials proving their benefit were funded by parties who profit, and points to FDA warnings on diabetes and memory problems.
Drug
Statin use may boost gallstone disease risk?
A Taiwanese case-control study of 1,014 gallstone patients and 1,014 controls aged 50 and over found statin users 6% more likely to be diagnosed, or 14% after adjustment, with risk reaching 30% at the highest cumulative doses. An earlier JAMA study reported the opposite.
Drug
Pantoprazole helps type 2 diabetes mellitus
In a 12-week randomized placebo-controlled trial in India, patients with type 2 diabetes who took pantoprazole had higher plasma gastrin and insulin, better beta-cell function and lower HbA1c. The authors say it may be the first trial of the drug's effect in these patients.
Drug
Chinese medicine helps acute myocardial infarction patients
Among 334 acute myocardial infarction patients, 2.96 percent of those given Chinese medicine alongside Western treatment were re-hospitalized for angina within six months, against 7.88 percent of controls. Chest pain, sweating and insomnia also eased in the treated group.
Drug
Bariatric surgery reduces disability risk in men with obesity
In a Swedish study of about 4,000 obese patients followed at least 10 years, men who had bariatric surgery were 21% less likely to draw a disability pension than those given conventional treatment. Without adjustment for baseline factors the difference vanished, and it did not appear in women.
Drug
In Mammogram Debate, Politics Trounces Science
Breast radiologist Handel Reynolds writes that mammography has been oversold as an early detector, citing Otis Brawley of the American Cancer Society admitting that screening's advantages have been exaggerated and JAMA research finding far more early-stage disease but little less late-stage.
Drug
It's unknown whether influenza vaccine helps the elderly
A review in Lancet Infectious Diseases screened more than 5,000 studies and kept 31 using lab-confirmed influenza. It found no solid trial evidence that flu vaccine protects people aged 65 and older; trivalent inactivated vaccine efficacy was shown only in adults 18 to 65.
Drug
Are You Ready for the Two Newly-Approved Diet Drugs?
With no new diet drug approved in 13 years and the last one, orlistat, remembered mostly for its digestive side effects, the piece sets up two newly approved obesity drugs against figures that 34 percent of US adults are obese and another 34 percent overweight.
Drug
Avastin more likely than Lucentis to cause eye problems
A PLoS One review of 11 randomised trials found patients given Avastin had about 1.8 times as many ocular adverse effects at one year as those given Lucentis, plus 30 percent more serious infections and gastrointestinal disorders. Two-year data showed more nonocular haemorrhage.
Drug
Does Low Income Mean More Medications?
Mercola cites a Forbes survey in which more than 10 percent of people earning under $25,000 took four or more prescription drugs, against none in the $100,000-plus group, and argues that Medicaid coverage and follow-up appointment incentives encourage polypharmacy.
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