Mercola's post defends Andrew Wakefield after the Lancet retraction, arguing autism is rising for environmental reasons and pointing to more than 1,300 vaccine-injury payouts for encephalopathy, encephalitis or seizure disorders as reason to keep the vaccine question open.
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Drug
Prescription drugs, vaccines and their risks and benefits.
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Drug
Long exposure to Tysabri increases risk of progressive multifocal leukoencephalopathy
FDA told doctors and patients that the risk of progressive multifocal leukoencephalopathy rises with the number of Tysabri infusions, citing 31 confirmed cases as of January 21, 2010. The label now carries this and IRIS information, but FDA says benefits still outweigh risks.
Drug
Oral contraceptive may boost breast cancer risk
Analyzing 1,197 cases and 2,015 controls, City of Hope researchers found women aged 45 to 64 who started oral contraceptives at 18 had 2.9 times the risk of triple-negative breast cancer. No link appeared for other subtypes, and long breastfeeding lowered risk.
Drug
Some swine flu vaccines may raise heart risk
Bhakdi and colleagues at Johannes Gutenberg University Mainz warned that the squalene-adjuvanted swine flu vaccines used in Europe might accelerate atherogenesis and raise cardiovascular risk. The FDA approved only non-adjuvanted versions in the United States.
Drug
Drug News: FDA expands use of breast cancer drug Tykerb
The FDA approved GlaxoSmithKline's Tykerb in combination with Novartis's Femara for hormone-positive, HER2-positive advanced breast cancer in postmenopausal women, after a study showed patients taking both lived longer than those on Femara alone.
Drug
Zyprexa (olanzapine): Use in Adolescents
Lilly and the FDA revised Zyprexa's prescribing information for adolescents aged 13 to 17, telling clinicians to weigh the greater potential for weight gain and hyperlipidemia than in adults and, in many cases, to consider prescribing other drugs first.
Drug
Birth control pill prevents pregnancy five days after sex
Scottish researchers tested ulipristal acetate against levonorgestrel in 1,600 women: 1.8 percent of ulipristal users became pregnant versus 2.6 percent on levonorgestrel. Among women treated more than three days after sex, none on ulipristal conceived; three others did.
Drug
Prostate cancer vaccine shows promise
A phase 2 trial of the Prostvac-VF vaccine in men with symptomatic castration-resistant metastatic prostate cancer reported a 44 percent lower death rate over three years, with 30 percent alive versus 17 percent of controls. One catch: vaccinated men averaged about four years younger.
Drug
Rotavirus vaccine cuts death risk from severe diarrhea
Two New England Journal of Medicine studies found rotavirus vaccination cut diarrhea deaths by 61 percent in Africa and 35 percent in Mexico. In South Africa and Malawi, 1.9 percent of vaccinated infants had severe diarrhea, against 5 percent of those given placebo.
Drug
FDA Approves New Treatment for Type 2 Diabetes (PR)
The FDA approved Victoza (liraglutide), a once-daily injection to lower blood sugar in some adults with type 2 diabetes alongside diet and exercise. In five trials of more than 3,900 people, pancreatitis occurred more often with Victoza than with other diabetes medicines.
Drug
FDA Approves First Percutaneous Heart Valve (PR)
The FDA approved Medtronic's Melody Transcatheter Pulmonary Valve, threaded up through a leg vein, for adults and children with failing pulmonary valve conduits. It does not cure the defect and may wear out, but it can delay open-heart surgery.
Drug
FDA warns against fake Alli again
The FDA alerted consumers to counterfeit Alli 60 mg refill kits sold over the internet that contained the controlled substance sibutramine instead of orlistat. Sibutramine can harm some patients and interact with other drugs; suspected counterfeits go to FDA criminal investigators.
Drug
FDA Okays Ampyra for Multiple Sclerosis
The FDA approved Ampyra (dalfampridine) to improve walking in multiple sclerosis. In two phase 3 trials, 34.8 and 42.9 percent of patients taking the 10mg tablet twice daily walked faster, against 8.3 and 9.3 percent on placebo, though the company says the size of the difference was not established.
Drug
EU: Weight Loss Pill too Risky
The European Medicines Agency told doctors to stop prescribing the weight loss drug sibutramine, concluding its heart risks outweigh the benefits. The FDA said in November 2009 it was reviewing data suggesting patients on the drug had more heart attacks, strokes and cardiac arrests.
Drug
Oral MS Drugs Promising - Studies
Three New England Journal of Medicine studies tested fingolimod and cladribine in oral form. In a 1,326-patient trial, cladribine lowered relapse rates and brain lesion counts, but lymphocytopenia and herpes zoster were more common; researchers said the benefits need weighing against the risks.
Drug
Johnson & Johnson recalls Tylenol
Johnson & Johnson's McNeil unit expanded its recall to all lots of 100-count Tylenol arthritis pain caplets over a musty odor traced to 2,4,6-tribromoanisole. At least 70 people reported nausea, stomach pain, vomiting and diarrhea, and the FDA sent McNeil a warning letter over the delay.
Drug
FDA approves rheumatoid arthritis drug for adults
The FDA approved Genentech's Actemra for adults with moderately to severely active rheumatoid arthritis who responded inadequately to existing treatments. The drug blocks IL-6, a protein behind joint inflammation, and was tested in five studies of more than 4,000 patients.
Drug
More evidence on benefits of high blood pressure drugs in diabetic eye disease (PR)
Scientists analyzed more than 1,700 retinal proteins in diabetic mice and found 65 abnormal ones; the ARB drug candesartan prevented the abnormal changes in over 70 percent. They say the work suggests blood pressure drugs may help prevent or treat diabetic retinopathy.
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