Saturday Nov 29, 2015 (foodconsumer.org) -- Patients with type 2 diabetes mellitus are at higher risk for renal stones, according to a new study recently published in Advanced Biomedical Research.  The study also suggests that individuals who are diagnosed with kidney stones may need to be checked out to see if they also suffer type 2 diabetes mellitus. 

The study found type 2 diabetes mellitus patients were more likely than those non-diabetics to form uric acid stones, 36% of total kidney stones in diabetics vs. 11% of total kidney stones in non-diabetics. The overall incidence of kidney stones including calcium oxalate and uric acid calculi was found at least 30% higher in those who lived with type 2 diabetes mellitus compared to those non-diabetics. 

The current study also found the high risk of nephrolithiasis associated with high urinary acidity or low urinary pH in patients with type 2 diabetes mellitus. In diabetics, urinary pH was 5.61 compared to 6.87 in individuals who did not have type 2 diabetes mellitus.  Note that the low pH is also a risk factor for cancer.  The low pH in type 2 diabetes mellitus may also explain why diabetics are at higher risk for cancer.  

To lower the risk of uric acid kidney stones or urinary stones, two things need to be done:  reducing the urinary uric acid load and increasing urinary pH.  Fructose can lead to the formation of uric acid.   So sugars should not be included in the diet for diabetes mellitus patients.   High urinary acid load can be found in type 2 diabetes mellitus patients because insulin resistance results in kidney ammoniagenesis.  Some substance often found in the kitchen can be used to raise the urinary pH and prevent or eliminate all sorts of kidney stones in both diabetics and non-diabetics. (david Liu)

Nerli R, Jali M, Guntaka AK, Patne P, Patil S, Hiremath MB. Type 2 diabetes mellitus and renal stones. Adv Biomed Res. 2015 Aug 31;4:180.

Hee is another study that links diabetes mellitus to elevated risk for kidney stones