Following 87,724 postmenopausal women in the Women's Health Initiative, researchers found that one or more drinks a day roughly doubled the risk of lobular and hormone receptor-positive breast cancer, but saw no increase in the far more common ductal type. Type of drink made no difference.
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Breast Cancer
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Cancer
Breast Cancer Risk: One Size May Not Fit All
USC researchers tracking 3,000 women from 1995 to 2006 found 15 years or more of estrogen therapy raised breast cancer risk 19%, and estrogen with progestin raised it 83%. Thinner women faced greater post-HRT risk than obese women, which the team did not explain.
Drug
Hormone replacement therapy boosts breast cancer risk, study confirms
Following almost 3,000 women for about 10 years, USC researchers found breast cancer risk climbed the longer hormone therapy lasted: 19% higher after 15 years of estrogen alone, 83% higher with estrogen plus progestin. Continuous users faced the highest risk of all.
Environment
Are Household Cleaners Linked to Breast Cancer?
An Environmental Health study asked about 800 women, half of them with breast cancer, about cleaning products and found the heaviest users of mold and mildew cleaners and air fresheners carried twice the risk of light users. Surface and oven cleaners showed no association.
Environment
Household appliances linked to breast cancer
An In Vivo study drew on 1,290 Israeli women aged 60 and older and found significantly more epithelial mammary tumors among those followed from 1991 to 2003, who used EMF-generating appliances heavily, than in the 1978-1990 group, who rarely did.
Supplements
Fish Oil, not Avastin, Fights Breast Cancer
An FDA advisory panel voted 12 to 1 to drop Avastin's breast cancer indication after follow-up studies failed to repeat its tumor-shrinking result. Separately, a lab study found omega-3 fatty acids downregulated a cancer-linked gene in breast cancer cells.
Environment
Household cleaning products linked to breast cancer
A case-control study in Environmental Health found women who used household cleaning products most often were 110 percent more likely to be diagnosed with breast cancer, and frequent air freshener users 90 percent more likely. Pesticides showed no link, and the data were self-reported.
Supplements
New evidence explains why fish oil fights breast cancer
Texas researchers report that a fish oil diet raised levels of the tumour suppressor PTEN in breast tumours in a mouse xenograft model, offering a mechanism for earlier observations, among them a cohort in which regular fish oil users were 32% less likely to develop breast cancer.
Supplements
Omega-3 fatty acids prevent breast cancer from spreading
DHA and EPA reduced the activity, though not the number, of CXCR4 receptors on MDA-MB-231 breast cancer cells, limiting their migration, researchers reported in Molecular Cancer Research. They call it a possible benefit for patients with metastatic breast cancer.
Supplements
Fish oil may reduce risk of breast cancer
Among 35,016 postmenopausal women followed six years, those who regularly used fish oil supplements were 32 percent less likely to develop breast cancer, particularly invasive ductal disease. The authors caution this is an association; a healthier lifestyle among users could explain it.
Drug
Findings Could Alter Breast Cancer Care
One study found lumpectomy, a standard breast cancer treatment, does not prolong survival or prevent recurrence for certain women. Another found that a single dose of radiation delivered to the tumor site right after surgery matched six weeks of daily radiation.
Cancer
Breast cancer survivors should take vitamin D - report
Mayo Clinic authors writing in Nutrition recommend breast cancer survivors keep adequate vitamin D stores for life, citing evidence that intake runs inversely to breast cancer risk, that higher levels track with better survival, and that up to 75 percent of patients are insufficient.
Drug
Sea Sponge Drug Fights Breast Cancer
In a trial of 762 women whose breast cancer had returned or spread, those given eribulin lived over 13 months against under 11 months for the comparison group. The drug, a synthetic analogue of a sea sponge compound, caused fatigue, low white cell counts, numbness and hair loss.
Cancer
Plant-based diet good for breast cancer survivors
In a small crossover study, 81 percent of breast cancer survivors who began with an olive oil-rich plant-based diet lost more than 5 percent of body weight, against 31 percent on the National Cancer Institute low-fat diet. Twenty-eight of 44 women completed both eight-week diets.
Food Chemicals
Prenatal exposure to BPA, DES may boost breast cancer risk
Pregnant mice exposed to BPA or DES produced offspring with raised levels of EZH2, a protein that controls gene expression and whose higher levels are linked to breast cancer risk in humans. Yale's Hugh Taylor says even weak estrogens can alter breast development.
Phytochemicals
Broccoli Component Limits Breast Cancer Stem Cells
Sulforaphane, a compound in broccoli, targeted and killed breast cancer stem cells and prevented new tumors in mice and cell cultures. Current chemotherapies do not work on these cells. Science Daily notes the concentrations used exceeded what eating broccoli provides.
Disease
Postmenopausal breast cancer preventable
Analysing Swedish registry and international incidence data, Hemminki and colleagues report the gap between high- and low-incidence countries lies mainly in postmenopausal breast cancer, which rose over the past century. Rates also differed sharply between white Californians and Asian immigrants.
Chemical
Well-done meat does not raise breast cancer risk
Analyzing Nurses' Health Study data on cooking methods, Wu K and colleagues found meat-derived heterocyclic amines showed no association with postmenopausal breast cancer; high MeIQx, PhIP and DiMeIQx intakes tracked with slightly less ER-negative disease.
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