Keith Bible's phase II trial found Votrient shrank tumours in about 49 percent of patients with radioiodine-refractory differentiated thyroid cancer, with a 66 percent chance of lasting a year. Side effects were common and any survival benefit remains unclear.
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Cancer
Diet, lifestyle and cancer risk, prevention and treatment.
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Cancer
FDA Delays Decision on Breast Cancer Drug
Genentech says the FDA has pushed back by 90 days, to December 17, its decision on revoking Avastin's breast cancer approval. An advisory panel voted 12-1 in July to withdraw it after follow-up studies showed the drug delayed worsening by only one month rather than the five originally reported.
Cancer
Childhood Cancer: Where are the Headlines?
Cancer kills more US children under 14 than any other disease. Over 12,400 are diagnosed each year and about 4,000 die, 11 a day. The piece describes what treatment costs families and siblings, and suggests practical help neighbours can offer.
Cancer
Please Help CHOP Childhood Cancer
About 11,000 US children will be diagnosed with cancer this year and more than 1,300 will die, making it the second leading cause of death in children. Children's Hospital of Philadelphia marks the awareness month by sharing patients' stories, including Tara Stout's.
Cancer
Pediatric Cancer: Cure Desperately Needed
Neuroblastoma, the most common cancer in infancy, accounts for about 650 of the more than 12,000 pediatric cancers diagnosed in the U.S. each year. It usually starts in an adrenal gland, its early symptoms are vague, and 50-60 percent have already spread by diagnosis.
Miscellaneous
Stand Up to Cancer 2010 - Another Fundraising Campaign for Cancer Research
The second Stand Up To Cancer telethon aired across ABC, NBC, CBS, Fox and many cable channels, co-hosted by Diane Sawyer, Brian Williams and Katie Couric, drawing scores of celebrities to solicit public donations for cancer research.
Cancer
Pediatric Cancer: Who Will Look for a Cure?
About 46 U.S. children and adolescents are diagnosed with cancer each day, more than 12,000 a year. Marking Pediatric Cancer Awareness Month, the piece follows Sam Bish, an Ohio 8-year-old who died a year after an osteosarcoma diagnosis, and the Pediatric Cancer Foundation's research funding.
Vitamins
Could This Simple Habit Actually Reduce Cancer and Diabetes by 50%?
Reuters reports that vitamin D influences more than 200 genes, among them genes tied to cancer and multiple sclerosis, acting through receptors that bind specific spots on the genome. Mercola cites over 800 cancer studies and claims optimal levels can halve the risk of several cancers.
Cancer
Research Sheds Light on Aggressive Breast Cancers
Breakthrough Breast Cancer researchers deleted BRCA1 from both basal and luminal cells in mice. Tumors arose in both, but only those from luminal cells carried the traits of human BRCA1 cancers, contrary to the assumption that such tumors start in basal cells.
Cancer
Michael Douglas diagnosed with throat cancer
Michael Douglas told David Letterman he was diagnosed with stage 4 throat cancer early in the summer and has finished the first week of an eight-week course of chemotherapy and radiation. He attributed it to drinking and smoking; his doctor's prognosis is a full recovery.
Cancer
Preventive Surgery Reduces Breast, Ovarian Cancer Risk
A JAMA study of 2,482 women carrying BRCA1 or BRCA2 mutations found prophylactic removal of the breasts, or of the ovaries and fallopian tubes, significantly lowered cancer risk compared with intensive screening. Because surgery cannot remove all breast tissue, some risk remains.
Food
Salmonella with Your Omelet? Don't forget Stroke and Ovarian Cancer
An opinion piece urging readers to stop buying eggs, citing salmonella, cholesterol, claimed links to diabetes and ovarian cancer, antibiotic residues, and undercover video of bloody, insect-covered eggs at a California farm.
Cancer
Breast Cancer Survivors Carry on - Despite TDM1 Hault
Roche says the FDA found its Phase II data for T-DM1, a conjugated antibody that shrank tumors in HER2-positive breast cancer, did not meet the standard for accelerated approval because other treatments had not been exhausted. Roche plans a submission from the Phase III EMILIA study in mid-2012.
Cancer
Breastfeeding Benefits Abound
A study of 2,200 women aged 40 to 78 found those who never breastfed were twice as likely to develop type 2 diabetes as those who did. Lead author Eleanor Bimla Schwarz attributes the difference to breastfeeding reducing maternal belly fat, a known diabetes risk factor.
Cancer
Cancer's Favorite Food - Found in Everything You Eat?
A Cancer Research study found pancreatic tumor cells handle fructose and glucose in different ways, using fructose to divide and proliferate. The finding challenges the idea that all sugars act alike and may bear on earlier links between fructose and pancreatic cancer.
Cancer
Fighting Back: New Drug for Melanoma
A genetically targeted drug aimed at the BRAF mutation shrank tumors in 80 percent of metastatic melanoma patients in a study led by Keith T. Flaherty, reported in the New England Journal of Medicine. Only two FDA-approved drugs currently treat the metastatic disease.
Cancer
Breast Cancer Linked to Nicotine, Alcohol
Two studies in the Journal of the National Cancer Institute: Taiwanese researchers found the alpha-9 nicotinic acetylcholine receptor subunit overproduced in 276 breast tumour samples, more so in advanced disease, while a second examined alcohol and breast cancer subtypes in 88,000 women.
Cancer
PSA Screening May Exaggerate Familial Predisposition
Swedish researchers led by Dr. Ola Bratt matched 13,975 prostate cancer patients with 22,511 of their brothers to test whether PSA screening inflates the apparent familial risk. Brothers of patients were diagnosed more often than men of the same age in the general population.
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