In a case-control study of 707 postmenopausal breast cancer patients and matched controls, each 20 ng/mL rise in plasma 25(OH)D3 was tied to 72 percent lower breast cancer risk among white women. The association did not hold in the other race and ethnic groups studied.
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Cancer
Diet, lifestyle and cancer risk, prevention and treatment.
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Cancer
A High-Fat Diet Increases Risk of Breast Cancer
Analysing 11.5 years of diet records from 337,327 women in the EPIC-Oxford study, researchers found those eating the most fat had a 20 percent higher risk of ER- and PR-positive breast cancer, and those eating the most saturated fat a 28 percent higher risk than the lowest consumers.
Cancer
Melatonin may slow tumor growth in certain breast cancers (PR)
In an early-stage animal study published in PLoS One, melatonin appeared to slow tumour growth and cell production and block new blood vessel formation in ER-negative breast cancer models. Researchers say the drug and its effect on tumours can now be traced.
Cancer
High folic acid promotes growth of breast cancer in rats (PR)
Folic acid at 2.5 to five times the daily requirement significantly promoted the growth of existing pre-cancerous and cancerous cells in the mammary glands of rats, Dr. Young-In Kim's lab reported in PLOS ONE. Breast cancer survivors in North America commonly take such supplements.
Cancer
Breast cancer risk higher in alchol drinkers
Over 12.4 years, women drinking 5 to 9.9 grams of alcohol a day had 23% higher breast cancer risk than non-drinkers, and those drinking over 30 grams 53% higher. Researchers say even light to moderate drinking raises risk; the pattern varied across ethnic groups.
Cancer
Dietary phytoesterols prevent breast cancer growth
In mice prone to breast cancer and fed a high-fat, high-cholesterol diet, dietary phytosterol supplements reduced mammary hyperplastic lesions and total tumor burden, the authors report.
Cancer
Added sugar linked to high risk of endometrial cancer
A case-control study comparing 424 women with endometrial cancer to 398 controls found the highest added sugar intake carried an 84 percent higher risk, rising further among women with a waist-to-hip ratio of 0.85 or more. The design cannot prove sugar caused the increase.
Cancer
Vitamin C increases efficacy of radiotherapy in cancer treatment
Japanese researchers applied 2.5 mM vitamin C to human leukemia cells and irradiated them at 2 Gy, getting an additive cytotoxic effect with lower mitochondrial membrane potential and more apoptosis. The Oncology Reports findings counter the worry that antioxidants blunt radiotherapy.
Cancer
Omega 6 polyunsaturated fatty acids promote breast cancer
A review argues that omega-6 polyunsaturated fats, found in soybean and corn oil, can promote breast cancer development, while extra virgin olive oil, high in monounsaturated fat, has been associated with reduced risk of the disease.
Cancer
Vitamin D may help prevent breast cancer
Comparing 120 Saudi women with breast cancer to 120 hospital controls, researchers found those with serum vitamin D below 10 ng/mL were six times as likely to be diagnosed as women above 20 ng/mL. The authors note this was not a trial and establishes no causal relationship.
Cancer
Calcium carbonate, vitamin E prevent cured meat induced colorectal cancer
A study in the American Journal of Clinical Nutrition reports that cured meat raised the formation of nitroso compounds and lipid peroxidation in rats, and that adding calcium carbonate and alpha-tocopherol to the meat offset those effects.
Cancer
Breaking news: Taking vitamin D supplements prevents lung cancer
A study in the American Journal of Clinical Nutrition linked more than 400 IU of vitamin D3 a day to 63% lower lung cancer risk among never-smoking postmenopausal women. It drew on 128,779 women in the Women's Health Initiative; smokers showed no such benefit.
Cancer
Soy foods help prevent breast cancer in BRCA mutation carriers
In the Korean Hereditary Breast Cancer Study, women with BRCA mutations in the top quartile of soy intake were 61% less likely to have breast cancer, while those eating the most meat faced 97% more risk, against 41% more for non-carriers.
Cancer
Vitamin D supplements may better breast cancer survival
Among 585 breast cancer survivors followed an average of 9.2 years, those with sufficient serum vitamin D were 42 percent less likely to die than deficient women. The authors stress the observational design cannot establish that vitamin D causes longer survival.
Cancer
Breast cancer, nutrition and physical activity - Breast Cancer Awareness Month
R.T. Chlebowski's review in the journal Breast ties lower dietary fat, weight loss, vitamin D and moderate activity of three to four hours of walking a week to reduced breast cancer risk and recurrence. He notes it is unknown whether the fat cut or the weight loss drives the benefit.
Cancer
Dietary vitamin C prevents breast cancer
Among 3,405 Swedish women with invasive breast cancer, those in the highest quartile of vitamin C intake before diagnosis were 25 percent less likely to die of the disease than those in the lowest, H.R. Harris and colleagues report in the British Journal of Cancer.
Cancer
Kills Cancer Cells Without Chemo... So Don't Slight This Easily Overlooked Food
University of East Anglia researchers are starting human trials after lab work showed sulforaphane, a broccoli compound, blocked an enzyme that damages cartilage in human and cow cartilage cells, tissue and live mice. Lead researcher Ian Clark calls the results “very promising.”
Cancer
Western diet linked to breast cancer
Franco Berrino's team randomized 104 postmenopausal women with high testosterone to intensive dietary counseling or no change for 4.5 months. The diet group raised sex hormone-binding globulin 25% versus 4% and cut testosterone 20% versus 7% in controls.
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