Comparing 253 chronic myelogenous leukemia patients with 270 controls, Texas researchers found patients were three to five times more likely to have been obese at 25, at 40 and at diagnosis. Those gaining more than 1 kg a year from 25 to 40 were 263 percent more likely to be diagnosed.
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Disease
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Disease
Breast cancer news: Breast milk may spread viruses that cause breast cancer
A study by W.K. Glenn and colleagues in BMC Research Notes found high-risk HPV and Epstein-Barr virus in human breast milk, raising the prospect of passing them to babies. An editor's note stresses breastfeeding's benefits outweigh its risks and that the HPV link is unsubstantiated.
Disease
Confirmed: Belly Fat is Far More Dangerous than Having a Total BMI in Obese Range
A study presented to the European Society of Cardiology found cardiovascular deaths 2.75 times higher among normal-weight people with large bellies than among those with both a normal BMI and a normal waist-to-hip ratio, suggesting fat distribution matters more than BMI.
Disease
Pancreatic cancer linked to type 2 diabetes mellitus
Comparing 182 pancreatic cancer patients with 135 people without the disease, Czech researchers found type 2 diabetes in 35.2 percent of the cancer group against 20.0 percent of controls, and the association was stronger in women than in men.
Disease
Author Offers Help For Families Dealing With Addiction
William C. Moyers discusses Now What?, his practical guide for addicts and their families on recognising when help is needed, navigating treatment and building support. He credits the Twelve Steps and describes the denial that surrounds addiction in families and in public.
Disease
High blood pressure does not raise death risk in the frail
Among 2,340 adults 65 and older in a national survey, high blood pressure was linked to greater mortality risk in those who walked faster than 0.8 meters per second, a measure of fitness, while frailer, slower walkers faced less risk from it, a study in Archives of Internal Medicine found.
Disease
Reversible Pulmonary Hypertension Linked to Whipple's Disease
Doctors in Milan report a 72-year-old woman whose pulmonary hypertension resolved after 40 days of antibiotics for Whipple's disease. Her pulmonary artery systolic pressure was 95 mmHg on admission, and a follow-up echocardiogram showed the right ventricle had normalized.
Disease
Mammographic density linked to breast cancer risk
In the Carolina Breast Cancer Study, covering 491 cases and 528 controls, women with the highest mammographic density had a 145 percent higher breast cancer risk than those with the lowest, in both black and white women. The association was stronger in white women.
Disease
Greater weight growth rate means better survival for cystic fibrosis patients
Among 3,142 Americans with cystic fibrosis born from 1989 to 1992, those with greater weight-for-age at 4 years had better lung function from 6 to 18, grew taller, had fewer pulmonary exacerbations and hospital visits, less diabetes by 18, and better survival through childhood.
Disease
Visceral obesity linked to prostate cancer
Comparing 63 prostate cancer patients with 63 age-matched controls by CT, Portuguese researchers found men with more visceral fat were 4.6 times as likely to have prostate cancer, and those with a higher visceral-to-subcutaneous fat ratio had a 130% higher risk.
Disease
FDA Update on Fungal Meningitis Outbreak
CDC and FDA confirmed the fungus Exserohilum rostratum in unopened methylprednisolone acetate vials from one implicated New England Compounding Center lot, the same fungus behind an outbreak that had caused 254 meningitis cases and 20 deaths. About 14,000 patients may be affected.
Disease
Lipoprotein (a) linked to peripheral artery disease
In the EPIC-Norfolk cohort, people with 2.7-fold higher lipoprotein(a) were 37 percent more likely to develop peripheral artery disease and 13 percent more likely to develop coronary artery disease, with no such link for ischemic stroke. LDL cholesterol levels did not modify the associations.
Disease
Multistate Outbreak of Fungal Meningitis linked to steroid shots — United States, 2012
A Tennessee meningitis case diagnosed 46 days after an epidural steroid injection opened an investigation that by October 10 had found 137 cases and 12 deaths in 10 states, all tied to three lots of methylprednisolone acetate compounded at the New England Compounding Center.
Disease
Polycystic ovary syndrome boosts type 2 diabetes risk
Italian researchers followed 255 women with polycystic ovary syndrome for a mean 16.9 years and found 42 developed type 2 diabetes, 6.7 times the rate in the general female population. They urge adding BMI, glucose and SHBG levels to risk stratification.
Disease
High testosterone may boost advanced liver disease risk
Among 308 male veterans with chronic hepatitis C, each 1-ng/mL rise in total serum testosterone came with 25 percent higher odds of advanced fibrosis. The authors say testosterone may matter in disease progression, but the cross-sectional design cannot show which came first.
Disease
CDC Update on Meningitis Outbreak: 91 cases, 7 deaths
The CDC reported 91 meningitis cases and 7 deaths tied to epidural steroid injections from a Boston compounding pharmacy, with Tennessee (32 cases) and Michigan (20) hardest hit. The piece notes such preparations escape FDA oversight and warns more cases may follow.
Disease
Epilepsy linked to sudden cardiac arrest
A Dutch case-control study of 1,019 sudden cardiac arrest cases with documented ventricular fibrillation and 2,834 controls found epilepsy associated with a threefold higher risk of sudden cardiac arrest, with the association strongest in the young and in women.
Disease
Radiation boosts breast cancer risk in women with BRCA1/2 mutations
Among 1,993 European carriers of BRCA1/2 mutations, any diagnostic radiation exposure before age 30 was linked to a 90 percent higher breast cancer risk, rising with dose, and mammography before 30 to a 43 percent increase. The authors favor MRI for surveillance in young carriers.
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