A BMJ Online First study following 5,700 patients with severe acne found suicide risk was already raised years before isotretinoin treatment and peaked in the six months after it ended, which researchers tie partly to disappointing results. They urge monitoring for a year after treatment.
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Vitamin D
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Vitamins
Vitamin D deficiency means higher death risk in Type 2 diabetes patients
Among 289 type 2 diabetes patients followed 15 years in Denmark, those with severe vitamin D deficiency, below 13.9 nmol/L, were 103 percent more likely to die of any cause and 95 percent more likely to die of cardiovascular disease than patients with higher levels.
Vitamins
Influenza, Flu Shots, and Vitamin D
Answering a reader who asks whether to get a flu shot or take vitamin D, Dr. Cannell says he does not know, but has come to believe vitamin D may be at least as protective as flu shots, while noting no head-to-head comparison has been done.
Vitamins
Vitamin D deficiency linked to learning deficit in Alzheimer's animals
Rats with Alzheimer's disease fed a vitamin D-free diet did worse in the Morris water maze than those on a supplemented diet, Iranian researchers report. Supplementation itself did not significantly change maze performance, leading the authors to urge protecting patients from deficiency.
Vitamins
Eczema, asthma and vitamin D
A reader's email to the Vitamin D Council asking Dr. Cannell whether his breastfeeding wife's and infant daughter's vitamin D doses are adequate and whether their eczema and asthma could be linked to vitamin D, preceded by an editor's appeal for donations to the organization.
Vitamins
Could vitamin D deficiency explain sepsis risk in elderly people?
A JAMA study of 516 survivors of severe sepsis, average age 77, found 60 percent worsened in cognitive or physical function, and survivors were 3.33 times more likely to develop moderate or severe cognitive impairment. One health observer suggested vitamin D deficiency may play a part.
Vitamins
Antioxidants may help prevent breast cancer
An Indian study in the Asian Pacific Journal of Cancer Prevention measured plasma antioxidants in 225 women and found higher beta-carotene, vitamin E and vitamin C accompanying significantly lower breast cancer risk. Higher vitamin A levels went the other way, tracking with higher risk.
Vitamins
Could vitamin D work better than influenza vaccine?
The CDC urges everyone six months and older to take the 2010-2011 flu shot. The piece counters that neither cdc.gov nor flu.gov mentions vitamin D3, and cites researchers William Grant and John Cannell, who argue high doses boost innate immunity against influenza.
Vitamins
Vitamin D helps prevent breast cancer recurrence, death - new study
Among 512 women with early breast cancer followed an average of 11.6 years, those deficient in vitamin D were 94 percent more likely to see a distant recurrence and 73 percent more likely to die than women with sufficient levels; after adjustment the gaps narrowed to 71 and 60 percent but held.
Vitamins
HIV carriers at risk of vitamin D deficiency
Blood samples from 115 Danish men with HIV showed 20 percent vitamin D deficient and 4 percent severely deficient, with another 27 percent insufficient. Levels were not linked to age, years infected, antiretroviral therapy or CD4 count.
Disease
Neonatal Jaundice Linked to Autism, Is Vitamin D the Missing Link?
A Danish study of 733,826 children published in Pediatrics found newborns with jaundice were 87 percent more likely to be diagnosed with a psychological disorder and, among those born at term, 56 percent more likely to have autism. Babies born October through March were 97 percent more likely.
Vitamins
Vitamin D protects against Parkinson disease
Among 3,173 Finnish adults followed 29 years, those with serum vitamin D in the highest quartile were 67 percent less likely to be diagnosed with Parkinson disease, after adjustment for factors including smoking, BMI and activity. The study is observational and shows no causal link.
Vitamins
Vitamin D helps prevent breast cancer
A German Cancer Research Center meta-analysis of ten studies found each 20 ng/mL rise in serum vitamin D accompanying 41 percent lower breast cancer risk in case-control studies and 8 percent in nested case-control studies. A Shanghai team's meta-analysis reached a similar conclusion.
Vitamins
The Vitamin D Newsletter: Yet another autism case report
A Vitamin D Newsletter exchange in which a mother of a three-year-old with autism spectrum disorder, verbal apraxia and hypotonia asks Dr. John Cannell to recommend a New York doctor who treats children with vitamin D, and he replies with a journal citation and follow-up questions.
Vitamins
Pink News: Aggressive Breast Cancer Linked To Vitamin D Deficiency
Researchers led by Susan Steck followed 107 women diagnosed with breast cancer in the previous five years, 60 of them black, and found African-American women had lower vitamin D levels than white women. The study links deficiency to a higher risk of aggressive breast cancer.
Drug
Electroconvulsive therapy recommended for major depression
The American Psychiatric Association's first depression guideline update since 2000 lists electroconvulsive therapy for major depressive disorder in patients with severe symptoms or no response to medication, and adds transcranial magnetic stimulation and vagus nerve stimulation.
Vitamins
Vitamin D: More Effective in Fighting Breast Cancer than Wearing Pink?
Engel and colleagues compared serum 25-hydroxyvitamin D in 636 women with breast cancer and 1,272 without, matched on age, menopausal status and collection details. The piece stresses the work does not prove vitamin D deficiency causes the disease.
Vitamins
The Vitamin D Newsletter: Another Tragedy
A Vitamin D Council newsletter prints a mother's letter: her five-and-a-half-week-old daughter's unexplained arm fracture, and later micro-fractures, led two hospitals to suspect child abuse. The baby's vitamin D was low-normal, the mother's was never tested, and neither took a full history.
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