In a 12-month trial of 39 Alzheimer's patients, Lynne Shinto's team found omega-3 fatty acids combined with alpha lipoic acid slowed functional and cognitive decline against placebo, though neither treatment moved F2-isoprostane levels. The authors call for more research.
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Supplements
Dietary supplements: evidence, safety and new products.
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Supplements
Pectinase-treated ginseng radix improves hyperglycemia and hyperlipidemia in diabetes patients
Mice fed a high-fat diet plus pectinase-treated red ginseng extract handled a glucose challenge better, and at the top 300 mg/kg dose showed fasting glucose and insulin down about 20 percent and insulin resistance down 36 percent, a Biological Therapy study reports.
Supplements
Glycine helps schizophrenia
In a study of 14 patients with schizophrenia, those given glycine rather than placebo showed significant improvement in negative symptoms, which the researchers attribute to glycine boosting NMDA-receptor neurotransmission. The piece adds background on glycine's other reported uses and doses.
Supplements
Low Testosterone and Heart Disease Linked—But What’s Really Causing Them?
An editor's note warns readers off testosterone supplements, claiming exogenous hormones raise disease risk and citing studies where castrated men outlived others, before handing over to a Mercola piece explaining what testosterone does in men and women.
Supplements
Melatonin Regulates Our Cycles, Mood, Reproduction, Weight and Even Cancer
Mercola presents melatonin as more than a sleep hormone: an antioxidant that crosses the blood-brain barrier and, in mice, reduced markers of brain aging. He links it to immune function, mood, weight and cancer prevention, and warns artificial light disrupts its production.
Supplements
Exogenous androgen use causes cortical venous thrombosis
A BMJ Case Reports paper from Karolinska University Hospital describes a young man who developed cortical venous thrombosis after taking an anabolic steroid at 20 mg a day for a month to build muscle. He was treated with heparin and then warfarin, and recovered four months later.
Supplements
Beta alanine, creatine monohydrate enhance endurance performance
In a 28-day double-blind trial, 55 men took placebo, creatine monohydrate, beta-alanine or both, and those on beta-alanine and creatine significantly extended time to exhaustion. A separate review found beta-alanine may raise power output and working capacity and reduce exercise fatigue.
Supplements
L-Carnitine: What you need to know
An overview of L-carnitine: the body makes it in the liver and kidneys from lysine and methionine, it carries long-chain fatty acids into mitochondria for energy, meat, fish, poultry and milk are the main sources, and it has been tested against heart, kidney and other conditions.
Supplements
Here is why ginger helps cardiovascular disease
Beijing researchers screened 89 compounds from 39 Chinese herbs and found ginger's [6]-gingerol acts as an angiotensin II type 1 receptor antagonist. They say this partly clarifies how ginger regulates blood pressure and strengthens the heart.
Supplements
Dietary cocoa tea extract may help weight loss
Mice on a high-fat diet supplemented with 2 or 4 percent cocoa tea lost weight and showed lower fat pad mass, liver lipids and plasma lipids, results the researchers call comparable to green tea. Cocoa tea is naturally decaffeinated; green tea is not.
Supplements
Tryptophan boosts serotonin in patients with depression
A 1971 Science study found tryptophan supplementation raised plasma and brain tryptophan and serotonin in rats. A 2013 Journal of Psychopharmacology study by Abdulla Badawy reports tryptophan is important in boosting brain serotonin synthesis in people with depression.
Supplements
Omega-3 fatty acids good for men's fertility
Chinese researchers fed 80 male rats diets with five different omega-3 to omega-6 ratios for two months. Rats at a ratio of 1.52 had higher sperm concentration and motility, better testis and sperm morphology, larger litters and heavier offspring. The work was done in rats.
Supplements
Resveratrol Supplement Lowers Blood Sugar in Type 2 Diabetic Patients
In a randomized, placebo-controlled trial, 66 people with type 2 diabetes took 1 g of resveratrol or placebo daily for 45 days alongside standard treatment. Systolic pressure, fasting glucose, HbA1c, insulin and insulin resistance fell in the resveratrol group, and HDL rose.
Supplements
Pomegranate Supplement helps Memory Dysfunction after Heart Surgery
Patients having bypass or valve surgery took 2 g a day of pomegranate extract from a week before surgery to six weeks after. The placebo group lost memory retention; the pomegranate group did not, and scored above their own pre-surgery baseline.
Supplements
Grape Seed Procyanidins and Hypertension
A controlled registry study gave 119 pre- and mildly hypertensive people 150 or 300 mg a day of a standardized grape seed procyanidin extract alongside diet and lifestyle changes. After four months both doses beat the control on all endpoints, with pressure normalizing in 93 percent at 300 mg.
Supplements
L-citrulline supplements help erectile dysfunction
In a Journal of Sexual Medicine study, rats with acute arteriogenic erectile dysfunction that drank 2 percent L-citrulline water for three weeks showed better ICP/MAP and smooth muscle/collagen ratios and higher nitric oxide levels. The authors call it a possible novel therapy.
Supplements
Melatonin a new weight loss medicine?
University of Granada researchers report in the Journal of Pineal Research that melatonin stimulates the production of beige fat, whose cells burn calories instead of storing them, which may help control weight gain. Their earlier work tested melatonin in young obese diabetic rats.
Supplements
What is Coenzyme Q10
An explainer on coenzyme Q10, an antioxidant found in nearly every cell that helps produce energy. It cites a trial in which heart attack patients taking CoQ10 within three days had fewer later attacks, and says supplements may ease swelling and breathing in heart failure.
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